Abstract
Berberine sulfate, an isoquinoline alkaloid isolated from Hydrastis canadensis L., inhibited the effects of the tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin, such as increased 32Pi-incorporation into phospholipids of cell membrane and hexose transport. Berberine sulfate also markedly suppressed the promoting effect of teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3-O-Methylglucose
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9,10-Dimethyl-1,2-benzanthracene
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Animals
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Berberine / pharmacology*
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Berberine Alkaloids / pharmacology*
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Biological Transport
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Carcinogens / antagonists & inhibitors*
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Cells, Cultured
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Female
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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HeLa Cells / drug effects
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HeLa Cells / metabolism
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In Vitro Techniques
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Lyngbya Toxins / antagonists & inhibitors*
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Methylglucosides / antagonists & inhibitors
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Methylglucosides / metabolism
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Mice
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Mice, Inbred ICR
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Neoplasms, Experimental / chemically induced*
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Phosphates / antagonists & inhibitors
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Phospholipids / metabolism
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Radioisotopes
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Skin / drug effects
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Skin Neoplasms / chemically induced
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Tetradecanoylphorbol Acetate / antagonists & inhibitors
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Time Factors
Substances
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Berberine Alkaloids
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Carcinogens
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Lyngbya Toxins
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Methylglucosides
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Phosphates
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Phospholipids
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Radioisotopes
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Berberine
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3-O-Methylglucose
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teleocidins
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9,10-Dimethyl-1,2-benzanthracene
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Tetradecanoylphorbol Acetate