Berberine Sulfate Inhibits Tumor-Promoting Activity of Teleocidin in Two-Stage Carcinogenesis on Mouse Skin

Oncology. 1986;43(2):131-4. doi: 10.1159/000226349.

Abstract

Berberine sulfate, an isoquinoline alkaloid isolated from Hydrastis canadensis L., inhibited the effects of the tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin, such as increased 32Pi-incorporation into phospholipids of cell membrane and hexose transport. Berberine sulfate also markedly suppressed the promoting effect of teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-O-Methylglucose
  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Berberine / pharmacology*
  • Berberine Alkaloids / pharmacology*
  • Biological Transport
  • Carcinogens / antagonists & inhibitors*
  • Cells, Cultured
  • Female
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism
  • HeLa Cells / drug effects
  • HeLa Cells / metabolism
  • In Vitro Techniques
  • Lyngbya Toxins / antagonists & inhibitors*
  • Methylglucosides / antagonists & inhibitors
  • Methylglucosides / metabolism
  • Mice
  • Mice, Inbred ICR
  • Neoplasms, Experimental / chemically induced*
  • Phosphates / antagonists & inhibitors
  • Phospholipids / metabolism
  • Radioisotopes
  • Skin / drug effects
  • Skin Neoplasms / chemically induced
  • Tetradecanoylphorbol Acetate / antagonists & inhibitors
  • Time Factors

Substances

  • Berberine Alkaloids
  • Carcinogens
  • Lyngbya Toxins
  • Methylglucosides
  • Phosphates
  • Phospholipids
  • Radioisotopes
  • Berberine
  • 3-O-Methylglucose
  • teleocidins
  • 9,10-Dimethyl-1,2-benzanthracene
  • Tetradecanoylphorbol Acetate