Antioxidant Activities of Vaccinium vitis-idaea L. Leaves within Cultivars and Their Phenolic Compounds

Molecules. 2019 Feb 27;24(5):844. doi: 10.3390/molecules24050844.


Lingonberry leaves are the subject of numerous studies because of antioxidant properties, positive influence on the health and potential use in the prevention and treatment of chronic diseases. In this work, the radical scavenging, reducing, chelating activities, and phenolic composition of ten lingonberry leaves cultivars, one subspecies, and one variety were investigated. Furthermore, the antioxidant activity of individual phenolic compounds, that can be found in lingonberry leaves, were analyzed, and structure-activity relationship was determined. Wide diversity for phenolic profile and antioxidant properties of lingonberry leaves has been observed in the present material. Cultivars 'Kostromskaja rozovaja', 'Rubin', and Vaccinium vitis-idaea var. leucocarpum surpassed all others tested cultivars and lower taxa by contents of phenolic compounds and antioxidant activity. Leaves of lingonberry cultivars and lower taxa are rich in arbutin, flavonol glycosides, proanthocyanidins, and the latter were considered to be the major contributor to antioxidant properties of lingonberry leaves.

Keywords: HPLC–PDA; Vaccinium vitis-idaea; antioxidant activity; lingonberry; phenolic compounds; structure-activity relationship.

MeSH terms

  • Antioxidants / pharmacology*
  • Chelating Agents / pharmacology
  • Free Radical Scavengers / pharmacology
  • Phenols / chemistry*
  • Phenols / pharmacology*
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry*
  • Vaccinium vitis-idaea / chemistry*


  • Antioxidants
  • Chelating Agents
  • Free Radical Scavengers
  • Phenols
  • Plant Extracts