Hepatic fibrosis is a wound healing and scar repair reaction after liver injury, and is a common pathway for various chronic liver diseases. Activation and proliferation of hepatic stellate cells are the key links in the occurrence and development of hepatic fibrosis. Recent studies have shown that long non-coding RNAs are involved in regulating the activation, proliferation and apoptosis of hepatic stellate cells. Thus, probing its mechanism of action will provide a new strategy for the diagnosis, treatment and prognosis in liver fibrosis.
肝纤维化是肝脏损伤后的创伤愈合和疤痕修复反应，是各种慢性肝病的共同通路。肝星状细胞活化、增殖等是肝纤维化发生、发展的关键环节。近年研究结果显示，长链非编码RNA参与调控肝星状细胞活化、增殖和凋亡，探讨其在肝纤维化的作用机制，将为肝纤维化的诊断、治疗和预后提供新的策略。.
Keywords: Hepatic stellate cell; Liver cirrhosis; Long non-coding RNAs.