Extracorporeal shockwave therapy (ESWT) is a novel treatment modality to stimulate tissue regeneration and anti-fibrosis. In this review, we summarise the use of ESWT for erectile dysfunction (ED), diabetic foot ulcers (DFU), Peyronie's disease (PD), chronic kidney disease (CKD), and scleroderma. Several randomised clinical trials demonstrate the efficacy of ESWT for vasculogenic ED and DFU, and ESWT may also relieve pain in patients with PD. ESWT is still experimental for CKD and scleroderma. In general, ESWT is associated with few and mild adverse effects.