Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination

Sailu Munnuri; Raghunath Reddy Anugu; John R Falck

doi:10.1021/acs.orglett.9b00586

Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination

Org Lett. 2019 Mar 15;21(6):1926-1929. doi: 10.1021/acs.orglett.9b00586. Epub 2019 Mar 1.

Authors

Sailu Munnuri¹, Raghunath Reddy Anugu¹, John R Falck¹

Affiliation

¹ Division of Chemistry, Department of Biochemistry , University of Texas Southwestern Medical Center , Dallas , Texas 75390-9038 , United States.

PMID: 30821980
DOI: 10.1021/acs.orglett.9b00586

Abstract

Cu(II)-mediated direct NH₂ and NH alkyl aryl aminations and olefin aziridinations are described. These room-temperature, one-pot, environmentally friendly procedures replace costly Rh₂ catalysts and, in some instances, display important differences with comparable Rh₂- and Fe-supported reactions.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemical synthesis
Alkenes / chemistry*
Amination
Aziridines / chemical synthesis
Aziridines / chemistry*
Catalysis
Copper / chemistry*
Molecular Structure

Substances

Alkenes
Aziridines
Copper