Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study

doi:10.1007/s10552-019-01148-4

. 2019 Apr;30(4):343-354.

doi: 10.1007/s10552-019-01148-4. Epub 2019 Mar 1.

Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study

Peijin Han¹, Aurelian Bidulescu², John R Barber¹, Steven H Zeisel³, Corinne E Joshu^{1

4}, Anna E Prizment⁵, Mara Z Vitolins⁶, Elizabeth A Platz^{7

8

9

10}

Affiliations

¹ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
² Department of Epidemiology and Biostatistics, Indiana University Bloomington School of Public Health, Bloomington, IN, USA.
³ Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴ Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
⁵ Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
⁶ Epidemiology & Prevention Office of Women in Medicine and Science Center on Diabetes, Obesity, and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁷ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. eplatz1@jhu.edu.
⁸ Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA. eplatz1@jhu.edu.
⁹ Department of Urology and the James Buchanan Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. eplatz1@jhu.edu.
¹⁰ , 615 N. Wolfe Street Room E6132, Baltimore, MD, 21205, USA. eplatz1@jhu.edu.

PMID: 30825046
PMCID: PMC6553878
DOI: 10.1007/s10552-019-01148-4

Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study

Peijin Han et al. Cancer Causes Control. 2019 Apr.

. 2019 Apr;30(4):343-354.

doi: 10.1007/s10552-019-01148-4. Epub 2019 Mar 1.

Authors

Peijin Han¹, Aurelian Bidulescu², John R Barber¹, Steven H Zeisel³, Corinne E Joshu^{1

4}, Anna E Prizment⁵, Mara Z Vitolins⁶, Elizabeth A Platz^{7

8

9

10}

Affiliations

¹ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
² Department of Epidemiology and Biostatistics, Indiana University Bloomington School of Public Health, Bloomington, IN, USA.
³ Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴ Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
⁵ Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
⁶ Epidemiology & Prevention Office of Women in Medicine and Science Center on Diabetes, Obesity, and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁷ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. eplatz1@jhu.edu.
⁸ Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA. eplatz1@jhu.edu.
⁹ Department of Urology and the James Buchanan Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. eplatz1@jhu.edu.
¹⁰ , 615 N. Wolfe Street Room E6132, Baltimore, MD, 21205, USA. eplatz1@jhu.edu.

PMID: 30825046
PMCID: PMC6553878
DOI: 10.1007/s10552-019-01148-4

Abstract

Purpose: Two prior cohort studies suggested that choline, but not betaine intake, is associated with an increased risk of advanced prostate cancer (PCa). Given that evidence remains limited, we evaluated whether intakes of choline and derivative betaine are associated with total and lethal PCa risk and PCa death in men with PCa.

Methods: We included 6,528 men (24.4% African American) without a cancer diagnosis at baseline (1987-1989) followed through 2012. Dietary intake was assessed using a food frequency questionnaire coupled with a nutrient database. We used Cox proportional hazards regression to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) of total and lethal PCa risk overall and by race.

Results: Choline intake was not associated with total (n = 811) or lethal (n = 95) PCa risk overall or by race. Betaine intake was inversely associated with lethal (tertile 3 vs 1, HR 0.59, 95% CI 0.35-1.00, p trend = 0.04), but not total PCa risk; patterns for lethal PCa were similar by race. Neither nutrient was associated with PCa death in men with PCa.

Conclusions: Choline intake was not associated with total or lethal PCa or with PCa death in men with PCa. Betaine intake was inversely associated with lethal, but not total PCa risk or with PCa death in men with PCa. Our results do not support the hypothesis that higher choline intake increases lethal PCa risk, but do suggest that higher betaine intake may be associated with lower lethal PCa risk. Further investigation with a larger number of lethal cases is needed.

Keywords: Case-fatality; Choline; Incidence; Lethal prostate cancer; Race.

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References

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1. Müller SA, Holzapfel K, Seidl C, Treiber U, Krause BJ, Senekowitsch-Schmidtke R (2009) Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment. Eur J Nucl Med Mol Imaging 36 (9):1434–1442. doi:10.1007/s00259-009-1117-x - DOI - PubMed

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[1] Newberne PM, Rogers AE (1986) Labile Methyl Groups and the Promotion of Cancer. Annu Rev Nutr 6 (1):407–432. doi:10.1146/annurev.nu.06.070186.002203 - DOI - PubMed

[2] Newberne PM, Rogers AE (1986) Labile Methyl Groups and the Promotion of Cancer. Annu Rev Nutr 6 (1):407–432. doi:10.1146/annurev.nu.06.070186.002203 - DOI - PubMed

[3] Balassiano K, Lima S, Jenab M, Overvad K, Tjonneland A, Boutron-Ruault MC, Clavel-Chapelon F, Canzian F, Kaaks R, Boeing H, Meidtner K, Trichopoulou A, Laglou P, Vineis P, Panico S, Palli D, Grioni S, Tumino R, Lund E, Bueno-de-Mesquita HB, Numans ME, Peeters PHM, Ramon Quirós J, Sánchez Ma-J, Navarro C, Ardanaz E, Dorronsoro M, Hallmans G, Stenling R, Ehrnström R, Regner S, Allen NE, Travis RC, Khaw K-T, Offerhaus GJA, Sala N, Riboli E, Hainaut P, Scoazec J-Y, Sylla BS, Gonzalez CA, Herceg Z (2011) Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST). Cancer Lett 311 (1):85–95. doi:10.1016/j.canlet.2011.06.038 - DOI - PubMed

[4] Balassiano K, Lima S, Jenab M, Overvad K, Tjonneland A, Boutron-Ruault MC, Clavel-Chapelon F, Canzian F, Kaaks R, Boeing H, Meidtner K, Trichopoulou A, Laglou P, Vineis P, Panico S, Palli D, Grioni S, Tumino R, Lund E, Bueno-de-Mesquita HB, Numans ME, Peeters PHM, Ramon Quirós J, Sánchez Ma-J, Navarro C, Ardanaz E, Dorronsoro M, Hallmans G, Stenling R, Ehrnström R, Regner S, Allen NE, Travis RC, Khaw K-T, Offerhaus GJA, Sala N, Riboli E, Hainaut P, Scoazec J-Y, Sylla BS, Gonzalez CA, Herceg Z (2011) Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST). Cancer Lett 311 (1):85–95. doi:10.1016/j.canlet.2011.06.038 - DOI - PubMed

[5] Johansson M, Van Guelpen B, Vollset SE, Hultdin J, Bergh A, Key T, Midttun O, Hallmans G, Ueland PM, Stattin P (2009) One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites. Cancer Epidemiol Biomark Prev 18 (5):1538–1543. doi:10.1158/1055-9965.EPI-08-1193 - DOI - PubMed

[6] Johansson M, Van Guelpen B, Vollset SE, Hultdin J, Bergh A, Key T, Midttun O, Hallmans G, Ueland PM, Stattin P (2009) One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites. Cancer Epidemiol Biomark Prev 18 (5):1538–1543. doi:10.1158/1055-9965.EPI-08-1193 - DOI - PubMed

[7] Keshari KR, Tsachres H, Iman R, Delos Santos L, Tabatabai ZL, Shinohara K, Vigneron DB, Kurhanewicz J (2011) Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage – impact of tissue environment. NMR in Biomed 24 (6):691–699. doi:10.1002/nbm.1738 - DOI - PMC - PubMed

[8] Keshari KR, Tsachres H, Iman R, Delos Santos L, Tabatabai ZL, Shinohara K, Vigneron DB, Kurhanewicz J (2011) Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage – impact of tissue environment. NMR in Biomed 24 (6):691–699. doi:10.1002/nbm.1738 - DOI - PMC - PubMed

[9] Müller SA, Holzapfel K, Seidl C, Treiber U, Krause BJ, Senekowitsch-Schmidtke R (2009) Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment. Eur J Nucl Med Mol Imaging 36 (9):1434–1442. doi:10.1007/s00259-009-1117-x - DOI - PubMed

[10] Müller SA, Holzapfel K, Seidl C, Treiber U, Krause BJ, Senekowitsch-Schmidtke R (2009) Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment. Eur J Nucl Med Mol Imaging 36 (9):1434–1442. doi:10.1007/s00259-009-1117-x - DOI - PubMed

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Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study

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Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study

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