[Effect of olivomycin on denervation changes in the membrane of frog tonic muscle fibers]

Tsitologiia. 1978 Apr;20(4):415-20.
[Article in Russian]

Abstract

Membrane properties of frog denervated tonic muscle fibers were investigated after the action of olivomycin, which is an inhibitor of protein synthesis. Olivomycin injected as a single dose (7.5 mg) during 1--2 days after the denervation of m. pyriformis decreases the regenerative action potentials. This action is decreased three weeks after denervation. After denervation, olivomycin failed to prevent the appearance of extrajunctional cholinoergic receptors, but blocked the increase of junctional ones. The data support the view that some neuronal factor may influence the synthesis of functional membrane proteins.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Anura
  • Male
  • Membrane Potentials / drug effects
  • Muscle Denervation*
  • Muscles / drug effects*
  • Neuromuscular Junction / drug effects
  • Olivomycins / pharmacology*
  • Rana temporaria
  • Receptors, Cholinergic / drug effects
  • Time Factors

Substances

  • Receptors, Cholinergic
  • Olivomycins