Position of Igl-1, md, and Bst loci on chromosome 16 of the mouse

Immunogenetics. 1986;23(2):78-83. doi: 10.1007/BF00377965.

Abstract

The experiments described here delineate the position of the chromosome 16 markers Igl-1 (immunoglobulin lambda 1, light chain), md (mahoganoid), and Bst (belly spot and tail), and suggest their location relative to the endogenous proviral locus Akv-2, which is linked within 5.9 centimorgans to Igl-1 (Epstein et al. 1984). The data from an intercross and a three-point backcross detailed herein show the order of these three genes and distances between them to be: centromere-md-10.4 +/- 1.6-Igl-1-15.6 +/- 2.6-Bst. Using a recombinant chromosome recovered in the intercross, we have constructed a stock homozygous for md and Igl-1b (KpnI-), that will aid in mapping other genes on chromosome 16.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AKR murine leukemia virus / genetics
  • Animals
  • Chromosome Mapping*
  • Crosses, Genetic
  • Female
  • Genetic Linkage
  • Hair Color
  • Immunoglobulin Light Chains / genetics*
  • Immunoglobulin lambda-Chains / genetics*
  • Male
  • Mice / genetics*
  • Mice, Inbred C57BL / genetics
  • Pigments, Biological / genetics*

Substances

  • Immunoglobulin Light Chains
  • Immunoglobulin lambda-Chains
  • Pigments, Biological