How much medication is delivered in a novel drug delivery technique that uses a tattoo machine?

Abstract

Background: Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety.

Objective: Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters.

Methods: Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery.

Results: In drug delivery done on human skin using a liquid with a density of 1,271,460 μg/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm² , and a needling depth of 300 microns, we estimate that 1,175 μg/cm² were delivered (standard deviation 601 μg/cm² , standard error 190 μg/cm² ).

Limitations: This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique.

Conclusion: The MMP drug delivery technique injects small amounts of medication (1,175 μg/cm² ) homogeneously into the dermis.