Automatic mapping of atrial fiber orientations for patient-specific modeling of cardiac electromechanics using image registration

Int J Numer Method Biomed Eng. 2019 Jun;35(6):e3190. doi: 10.1002/cnm.3190. Epub 2019 Mar 14.


Knowledge of appropriate local fiber architecture is necessary to simulate patient-specific electromechanics in the human heart. However, it is not yet possible to reliably measure in vivo fiber directions especially in human atria. Thus, we present a method that defines the fiber architecture in arbitrarily shaped atria using image registration and reorientation methods based on atlas atria with fibers predefined from detailed histological observations. Thereby, it is possible to generate detailed fiber families in every new patient-specific geometry in an automated, time-efficient process. We demonstrate the good performance of the image registration and fiber definition on 10 differently shaped human atria. Additionally, we show that characteristics of the electrophysiological activation pattern that appear in the atlas atria also appear in the patients' atria. We arrive to analogous conclusions for coupled electro-mechano-hemodynamical computations.

Keywords: atrial fiber orientation; cardiac electromechanics; patient-specific modeling.

MeSH terms

  • Anatomic Landmarks
  • Atrial Function / physiology
  • Automation
  • Biomechanical Phenomena
  • Computer Simulation
  • Electrophysiological Phenomena
  • Heart Atria / anatomy & histology*
  • Heart Atria / diagnostic imaging*
  • Humans
  • Image Processing, Computer-Assisted*
  • Models, Cardiovascular*
  • Myocardial Contraction
  • Patient-Specific Modeling*
  • Pressure
  • Stroke Volume
  • Time Factors