Investigation of antiaging and skin rejuvenation potential of phyto-constituents from Pyrus communis loaded topical emulgel

Pak J Pharm Sci. 2019 Jan;32(1(Supplementary)):293-300.


Pyrus communis fruit is traditionally used for improving the skin color and texture. The current study was designed to investigate Pyrus communis fruit phytoconstituents and their in-vivo rejuvenation effects on human skin by developing a stable emulgel formulation. Hydro-alcoholic extract of Pyrus communis was subjected to phytochemical analysis (TPC, TFC, antioxidant activity and anti-tyrosinase activity). A stable emulgel formulation loaded with 5% (w/w) Pyrus communis fruit extract was developed. Afterwards, this stable emulgel formulation was tested for effects on skin parameters and compared these with placebo (without fruit extract) by employing them on healthy human volunteers (n=13) for 3 months. Investigated in-vivo skin parameters were skin erythema, melanin, moisture, sebum and elasticity. Pyrus communis fruit extract showed excellent antioxidant and anti-tyrosinase activities. The developed formulation was stable in varying conditions of temperature and humidity for a period of 12 weeks. The active formulation showed statistically significant (p<0.05) decrease in skin melanin, erythema and sebum level while increase in skin elasticity and moisture content when compared with placebo. From findings it is concluded that Pyrus communis fruit extract loaded emulgel possesses antiaging potential with improvement in skin tone and elasticity, ameliorated skin moisture and showed skin whitening potential.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antioxidants / pharmacology
  • Emulsions / chemistry*
  • Emulsions / pharmacology
  • Erythema / drug therapy
  • Female
  • Flavonoids / analysis
  • Gels / pharmacology
  • Humans
  • Melanins / metabolism
  • Phenols / analysis
  • Phytochemicals / chemistry
  • Phytochemicals / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Pyrus / chemistry*
  • Rejuvenation
  • Sebum / drug effects
  • Skin / drug effects*
  • Sun Protection Factor*


  • Antioxidants
  • Emulsions
  • Flavonoids
  • Gels
  • Melanins
  • Phenols
  • Phytochemicals
  • Plant Extracts