Incidentally Detected Oropharyngeal Squamous Cell Carcinoma on 18F-Fluciclovine PET/CT

Clin Nucl Med. 2019 May;44(5):e367-e369. doi: 10.1097/RLU.0000000000002507.

Abstract

We present a case of oropharyngeal squamous cell carcinoma (SCC) of the tongue base incidentally detected on F-fluciclovine PET/CT. A 79-year-old man with history of locally advanced prostate cancer (Gleason score 4 + 5 = 9; cT2cN1M0) previously treated with androgen deprivation therapy (luprolide + bicalutamide) presented with a slowly rising serum prostate-specific antigen over 3 years, concerning for recurrent disease. F-fluciclovine PET/CT, obtained to identify potential sites of recurrence, demonstrated prostate bed uptake with possible left seminal vesicle involvement. Additionally, an exophytic, tracer-avid right tongue base mass was incidentally noted and later confirmed to be p16+ SCC on biopsy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carboxylic Acids
  • Carcinoma, Squamous Cell / diagnostic imaging*
  • Cyclobutanes
  • Fluorodeoxyglucose F18
  • Humans
  • Incidental Findings
  • Male
  • Oropharyngeal Neoplasms / diagnostic imaging*
  • Positron Emission Tomography Computed Tomography*
  • Radiopharmaceuticals

Substances

  • Carboxylic Acids
  • Cyclobutanes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • fluciclovine F-18