Management of Acute Ischemic Stroke

Am J Med. 2019 Mar;132(3):286-291. doi: 10.1016/j.amjmed.2018.10.019. Epub 2018 Oct 26.

Abstract

The treatment of acute ischemic stroke includes both intravenous (IV) thrombolysis and mechanical thrombectomy. Important advances regarding both treatment modalities have occurred recently that all physicians who see patients at risk for or who have had a stroke should be aware of. This review will focus on recent clinical trials of IV thrombolysis both positive and negative. Additionally, the results of a large number of early and late time window thrombectomy trials will be presented that demonstrate the remarkable efficacy of this treatment for appropriately selected patients.

Keywords: Endovascular; Stroke; Thrombectomy; Thrombolysis; tPA..

Publication types

  • Review

MeSH terms

  • Brain Ischemia / therapy*
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Patient Selection
  • Stroke / therapy*
  • Tenecteplase / therapeutic use
  • Thrombectomy / methods*
  • Thrombolytic Therapy / methods*
  • Time Factors
  • Time-to-Treatment
  • Tissue Plasminogen Activator / therapeutic use

Substances

  • Fibrinolytic Agents
  • Tissue Plasminogen Activator
  • Tenecteplase