The following case report describes the reconstruction of Fournier's gangrene (FG) which failed initial conventional primary closure due to issues with wound edge friability, large dead spaces, and significant tension and shearing forces created by excess adipose tissue in the patient's groin. In the first reported case that could be found in the literature ARTISS (Baxter), a low thrombin concentration fibrin sealant was used as a tissue adhesive to close the large post FG debridement wound flaps and ensure enough working time to allow for precise wound edge approximation. Employing Artiss in the closure of the large wound allowed for successful healing where simple primary closure had failed, aided an expedient recovery and reduced post reconstructive morbidity.