Implantable Multi-Modality Probe for Subdural Simultaneous Measurement of Electrophysiology, Hemodynamics, and Temperature Distribution

IEEE Trans Biomed Eng. 2019 Nov;66(11):3204-3211. doi: 10.1109/TBME.2019.2902189. Epub 2019 Feb 28.


Objective: The purpose of this paper is to demonstrate how the integration of the multi-channel measurement capabilities of near-infrared spectroscopy (NIRS), electrocorticography (ECoG), and negative temperature coefficient thermistor sensors into a single device compact enough for subdural implantation can provide beneficial information on various aspects of brain cortical activity and prove a powerful medical modality for pre-, intra-, and post-operative diagnoses in neurosurgery.

Methods: The development of a flexible multi-modal multi-channel probe for the simultaneous measurement of the NIRS, ECoG, and surficial temperature obtained from the cerebral cortex was carried out. Photoelectric bare chips for NIRS channels, miniature temperature-coefficient thermistors for measuring localized temperature variation, and 3-mm-diameter platinum plates for ECoG recording were assembled on a polyimide-based flexible printed circuit to create six channels for each modality. A conformal coating of Parylene-C was applied on all the channels except the ECoG to make the probe surface biocompatible.

Results: As a first-in-human study, the simultaneous measurement capability of the multi-modality probe, with sufficient signal-to-noise ratio and accuracy, to observe pathological neural activities in subjects during surgery and post-operative monitoring, with no complications two weeks since the implantation, was confirmed.

Conclusion: The feasibility of using a single device to assess the dynamic pathological activity from three different aspects was determined for human patients.

Significance: The simultaneous and accurate multi-channel recording of electrical, hemodynamic, and thermographic cortical activities in a single device small enough for subdural implantation is likely to have major implications in neurosurgery and neuroscience.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Temperature / physiology
  • Electrocorticography / instrumentation*
  • Equipment Design
  • Hemodynamics / physiology
  • Humans
  • Monitoring, Intraoperative / instrumentation
  • Monitoring, Intraoperative / methods
  • Monitoring, Physiologic* / instrumentation
  • Monitoring, Physiologic* / methods
  • Spectroscopy, Near-Infrared / instrumentation*
  • Subdural Space / physiology*
  • Thermometry / instrumentation*