Chromosome Segregation: Poor Supervision in the Early Stage of Life

Curr Biol. 2019 Mar 4;29(5):R156-R158. doi: 10.1016/j.cub.2019.01.036.

Abstract

Abnormal chromosome number, or aneuploidy, is common in early mammalian embryos, although the underlying cell biological basis is still incompletely understood. New research reveals that cells often fail to wait for all chromosomes to properly attach to the spindle machinery before segregation, explaining why early embryonic cell cycles are so error-prone.

Publication types

  • Comment

MeSH terms

  • Aneuploidy*
  • Animals
  • Cell Cycle Checkpoints
  • Cell Size
  • Chromosome Segregation*
  • Chromosomes
  • Mice