Background/aims: Identification of nutritional indicators to predict short-term and long-term outcomes is necessary to provide appropriate treatment to patients with gastric cancer.
Methods: We designed an analysis of a multicenter dataset of patients with gastric cancer who underwent gastrectomy between 2010 and 2014. We enrolled 842 eligible patients who had stage II/III gastric cancer. The area under the curve (AUC) values were compared among prognostic nutritional index (PNI), calculated as 10 × albumin g/dL + 0.005 × total lymphocyte count/mm3, and its constituents, and the predictive value of preoperative PNI for postoperative short-term and long-term outcomes was evaluated.
Results: Preoperative PNI exhibited higher AUC values (0.719) for 1-year survival than its constituents, and the optimal cutoff value was 47. The disease-free and overall survival of patients in the PNI-low group were significantly shorter compared with those in the PNI-high group. The prognostic difference between the PNI-high and PNI-low groups was significantly greater in the subgroup of patients who underwent total gastrectomy. Clinically relevant postoperative complications were more frequently observed in the PNI-low group.
Conclusions: The preoperative PNI is a useful predictor reflecting the incidence of complications after gastrectomy and the prognosis of patients with stage II/III gastric cancer.
Keywords: Gastric cancer; Postoperative complication; Prognosis; Prognostic nutritional index.
© 2019 S. Karger AG, Basel.
Nutritional Predictors for Postoperative Short-Term and Long-Term Outcomes of Patients With Gastric CancerM Kanda et al. Medicine (Baltimore) 95 (24), e3781. PMID 27310954.Evidence indicates that impaired immunocompetence and nutritional status adversely affect short-term and long-term outcomes of patients with cancer. We aimed to evaluate …
The Prognostic Nutritional Index Predicts Long-Term Outcomes of Gastric Cancer Patients Independent of Tumor StageK Migita et al. Ann Surg Oncol 20 (8), 2647-54. PMID 23463091.The PNI is a simple and useful marker for predicting the long-term outcomes of gastric cancer patients independent of the tumor stage. Based on our results, we suggest th …
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The Prognostic Nutritional Index Is a Predictive Indicator of Prognosis and Postoperative Complications in Gastric Cancer: A Meta-AnalysisY Yang et al. Eur J Surg Oncol 42 (8), 1176-82. PMID 27293109. - ReviewPNI was a predictive indicator of survival and postoperative complications, and was associated with clinicopathological features in GC patients. However, a low PNI was no …
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Cited by 2 PubMed Central articles
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