The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat

Diabetologia. 1986 Mar;29(3):168-74. doi: 10.1007/BF02427088.


This study examined the effects of an aldose reductase inhibitor, Sorbinil, on neuropathy over a 6-month period in streptozotocin-diabetic rats. Sorbinil treatment prevented the 10-fold increase in nerve sorbitol found with diabetes. It produced a 60% improvement in tibial nerve motor conduction velocity after 6 months. Morphometric profiles of nerves were also normalized. Axon area was reduced by 14% in untreated diabetic rats compared to age-matched controls, whereas Sorbinil-treated animals showed normal age-related axon growth. Myelin area was increased by 28% in untreated diabetic animals, but was the same as age-matched controls with Sorbinil treatment. Nerve myo-inositol levels were reduced by 45% after three months of untreated diabetes, but were normal after six months. Sorbinil treatment tended to restore myo-inositol levels toward normal over the shorter time period. It was concluded that axon growth retardation is the most likely cause of the conduction deficit seen in long-term experimental diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aldehyde Reductase / antagonists & inhibitors*
  • Animals
  • Axons / pathology
  • Blood Glucose / analysis
  • Body Weight
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / physiopathology*
  • Imidazoles / pharmacology*
  • Imidazolidines*
  • Inositol / analysis
  • Male
  • Myelin Sheath / pathology
  • Neural Conduction / drug effects*
  • Peripheral Nerves / analysis
  • Peripheral Nerves / drug effects*
  • Peripheral Nerves / pathology
  • Polymers / analysis*
  • Rats
  • Rats, Inbred Strains
  • Sciatic Nerve / analysis
  • Sugar Alcohol Dehydrogenases / antagonists & inhibitors*


  • Blood Glucose
  • Imidazoles
  • Imidazolidines
  • Polymers
  • polyol
  • Inositol
  • Sugar Alcohol Dehydrogenases
  • Aldehyde Reductase
  • sorbinil