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Review
, 101 (5), 774-778

Ketamine: A Paradigm Shift for Depression Research and Treatment

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Review

Ketamine: A Paradigm Shift for Depression Research and Treatment

John H Krystal et al. Neuron.

Abstract

Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy.

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