Advancing Translational Research Using NIMH Research Domain Criteria and Computational Methods

Charles A Sanislow; Michele Ferrante; Jennifer Pacheco; Matthew V Rudorfer; Sarah E Morris

doi:10.1016/j.neuron.2019.02.024

Advancing Translational Research Using NIMH Research Domain Criteria and Computational Methods

Neuron. 2019 Mar 6;101(5):779-782. doi: 10.1016/j.neuron.2019.02.024.

Authors

Charles A Sanislow¹, Michele Ferrante², Jennifer Pacheco³, Matthew V Rudorfer⁴, Sarah E Morris⁵

Affiliations

¹ Department of Psychology, Program in Neuroscience and Behavior, Wesleyan University, Middletown, CT 06459, USA; Department of Psychiatry, Yale University, New Haven, CT, USA.
² Division of Translational Research, National Institute of Mental Health, Bethesda, MD 20892, USA; Division of Neuroscience and Basic Behavioral Research, National Institute of Mental Health, Bethesda, MD 20892, USA.
³ Division of Translational Research, National Institute of Mental Health, Bethesda, MD 20892, USA; RDoC Unit, National Institute of Mental Health, Bethesda, MD 20892, USA.
⁴ Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892, USA.
⁵ Division of Translational Research, National Institute of Mental Health, Bethesda, MD 20892, USA; RDoC Unit, National Institute of Mental Health, Bethesda, MD 20892, USA. Electronic address: sarah.morris@nih.gov.

PMID: 30844398
DOI: 10.1016/j.neuron.2019.02.024

Abstract

The NIMH Research Domain Criteria (RDoC) can aid in the translation of integrative neuroscience. We argue that the RDoC framework, with its emphasis on integration across units of analysis, leveraged with computational approaches, can organize intermediary treatment targets and clinical outcomes, augmenting the translational stream.

Keywords: NIMH; RDoC; computational; precision medicine; translational; treatment targets.

MeSH terms

Computing Methodologies*
Humans
Mental Disorders / therapy*
National Institute of Mental Health (U.S.)*
Neurosciences / methods
Precision Medicine / methods
Translational Research, Biomedical / methods*
Translational Research, Biomedical / organization & administration
United States