Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 22, 101737

Mirror Neuron Activations in Encoding of Psychic Pain in Borderline Personality Disorder

Affiliations

Mirror Neuron Activations in Encoding of Psychic Pain in Borderline Personality Disorder

Zrinka Sosic-Vasic et al. Neuroimage Clin.

Abstract

Borderline personality disorder (BPD) is characterized by pronounced emotional instability in interpersonal relations. Previous studies have shown increased activity in the amygdala, an imaging phenotype of negative affect. However, clinical accounts of BPD have drawn attention to deficits in social cognition and their likely role in engendering emotional instability. BPD patients show enhanced sensitivity to other people's emotions, while being less proficient in reading motives and reasons. In the present functional imaging study, we exposed BPD participants to stylized scenes of individuals affected by loss or separation, an issue to which these patients are particularly sensitive. Previously shown to activate the mirror neuron system, these mourning scenes were here also used to assess differential amygdala activity in stimuli of negative valence, but low arousal. Relative to controls, BPD patients were found to activate sensorimotor areas, a part of the mirror neuron system thought to encode basic aspects of the perception of motoric activity and pain. This contrasted with the activity of areas related to more complex aspects of social cognition, such as the inferior frontal gyrus. The amygdala was more active in patients when viewing these scenes, but this effect also showed a strong association with levels of depressiveness and neuroticism. After adjusting for these covariates, differences in amygdala activation were no longer significant. These findings are consistent with models of social cognition in BPD that attribute emotional sensitivity to emotional contagion through the mirror neuron system, in contrast to areas associated with more sophisticated forms of social cognition. These effects were accompanied by increased amygdala reactivity, consistently with the common occurrence of affective symptoms in these patients.

Keywords: Borderline personality disorder; Empathy; Mirror neuron system; Neurobiological models of borderline personality disorder; Neuroimaging of borderline personality disorder.

Figures

Fig. 1
Fig. 1
Schematic representation of the passive exposure task.
Fig. 2
Fig. 2
Left: effect of pictures vs. baseline in the right amygdala, overlaid on a template brain. For display purposes, t maps were thresholded at p < .01, uncorrected. Slice location shown in MNI coordinates. Right: effect size shown separately in healthy controls and BPD individuals in neutral and mourning pictures.
Fig. 3
Fig. 3
Contrast BPD individuals vs. healthy controls for the mourning vs. neutral pictures comparison (top row), overlaid on a template brain. Bottom row: separate comparisons for the healthy and BPD groups. For display purposes, t maps were thresholded at p < .01, uncorrected. Slice locations shown in MNI coordinates. MCing; middle cingular cortex; Post. ins.: posterior insula; SensMot: sensorimotor cortex.

Similar articles

See all similar articles

References

    1. Adolphs R. Neural systems for recognizing emotion. Curr. Opin. Neurobiol. 2002;12:169–177. - PubMed
    1. Adolphs R., Damasio H., Tranel D., Cooper G., Damasio A.R. A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mapping. J. Neurosci. 2000;20:2683–2690. - PMC - PubMed
    1. Amunts K., Kedo O., Kindler M., Pieperhoff P., Mohlberg H., Shah N.J., Habel U., Schneider F., Zilles K. Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: Intersubject variability and probability maps. Anat. Embryol. 2005;210:343–352. - PubMed
    1. Belsky D.W., Caspi A., Arsenault L., Bleidorn W., Fonagy P., Goodman M., Houts R., Moffitt T.E. Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children. Dev. Psychopathol. 2012;24:251–265. - PMC - PubMed
    1. Bender D.S., Skodol A.E. Borderline personality as a self-other representational disturbance. J. Pers. Disord. 2007;21:500–517. - PubMed

LinkOut - more resources

Feedback