Speckle-interferometry and speckle-correlometry of GB-speckles

Front Biosci (Landmark Ed). 2019 Mar 1;24:700-711.


A new method of coding of genetic information using laser speckles has been developed. Specific technique of transforming the nucleotide of gene into a speckle pattern (gene-based speckles or GB-speckles) is suggested. Reference speckle patterns of omp1 gene of typical wild strains of Chlamydia trachomatis of genovars D, E, F, G, and J are generated. This is the first report in which perspectives of the proposed technique in the bacterial gene identification and detection of natural genetic mutations in bacteria as a single nucleotide polymorphism (SNP) are demonstrated. The usage of GB-speckles can be viewed as the next step on the way to the era of digital biology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Bacteria / genetics
  • Chlamydia trachomatis / genetics
  • Computational Biology
  • Databases, Genetic
  • Genotype
  • Information Storage and Retrieval / methods*
  • Interferometry / methods*
  • Lasers*
  • Mutation
  • Nucleotides / chemistry*
  • Optics and Photonics
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Porins / genetics
  • Sequence Analysis, DNA
  • Signal Processing, Computer-Assisted


  • Nucleotides
  • Porins
  • omp1 protein, Chlamydia trachomatis