Risk Factors for Compromised Surgical Resection: A Nationwide Propensity Score-Matched Study on Laparoscopic and Open Resection for Colonic Cancer

Dis Colon Rectum. 2019 Apr;62(4):438-446. doi: 10.1097/DCR.0000000000001304.


Background: High-quality surgical resection of colonic cancer, including dissection along the embryologic mesocolic plane, translates into improved long-term oncological outcomes.

Objective: This study aimed to identify risk factors for compromised specimen quality and to evaluate the specimen quality of patients undergoing laparoscopic and open resection for colonic cancer.

Design: This is a retrospective observational study.

Settings: This database study is based on the prospective national Danish Colorectal Cancer Database including patients undergoing intended curative elective colonic cancer surgery from January 1, 2010 through December 2013.

Patients: A total of 5143 patients (1602 open resections; 3541 laparoscopic resections) with colonic cancer were included.

Main outcome measures: Risk factors for poor resection quality were identified through uni- and multivariate logistic regression analysis. The surgical approach was assessed by propensity score-matched regression analysis. Poor resection quality was defined as resections in the muscularis plane accompanied by R0 resection, or resections in any resection plane accompanied by R1 resection.

Results: Overall, 4415 (85.8%) of the resections were considered good and 728 (14.2%) were considered poor. After multivariate analysis, neoadjuvant oncological treatment, advanced tumor stage (T3-4), advancing N stage (N1-2), open tumor perforation, and open surgery significantly increased the risk of poor resection quality. In a propensity score-matched sample (n = 1508 matched pairs), matched for age, sex, ASA score, BMI, neoadjuvant treatment, tumor stage, and tumor location, open resection was still associated with a higher risk of poor resection quality compared with laparoscopic resection (OR, 1.4; 95% CI, 1.1-1.8; p = 0.002).

Limitations: Retrospective design was a limitation of this study.

Conclusions: In this nationwide propensity score-matched database study, laparoscopic resection was associated with a higher probability of good resection quality compared with open resection for colonic cancer. Risk factors for compromised specimen quality were neoadjuvant oncological treatment, locally advanced tumor stage (T3-4), advanced N stage (N1-2), open tumor perforation, and open surgery. See Video Abstract at http://links.lww.com/DCR/A830.

Publication types

  • Video-Audio Media

MeSH terms

  • Aged
  • Colectomy* / adverse effects
  • Colectomy* / methods
  • Colectomy* / standards
  • Colonic Neoplasms* / pathology
  • Colonic Neoplasms* / surgery
  • Databases, Factual / statistics & numerical data
  • Denmark / epidemiology
  • Female
  • Humans
  • Laparoscopy* / adverse effects
  • Laparoscopy* / methods
  • Male
  • Neoadjuvant Therapy* / methods
  • Neoadjuvant Therapy* / statistics & numerical data
  • Neoplasm Staging
  • Outcome Assessment, Health Care / statistics & numerical data
  • Postoperative Complications* / classification
  • Postoperative Complications* / epidemiology
  • Propensity Score
  • Quality Improvement
  • Retrospective Studies
  • Risk Factors