Optimal choice of OSEM and SD reconstruction algorithms in CZT SPECT for hypertrophic cardiomyopathy patients

J Nucl Cardiol. 2021 Feb;28(1):236-244. doi: 10.1007/s12350-019-01677-0. Epub 2019 Mar 7.


Background: The spectrum dynamics (SD) algorithm is a cardiac reconstruction algorithm of D-SPECT, which improves spatial resolution compared with the ordered-subsets expectation maximization (OSEM) algorithm. We evaluated the wall thickness and left ventricular (LV) volume in patients with hypertrophic cardiomyopathy (HCM) using the SD algorithm.

Methods: In a phantom study, the myocardial wall was scanned with varying wall thicknesses (10-40 mm). In the clinical study, 30 and 27 normal and HCM patients underwent myocardial perfusion imaging.

Results: In a phantom study, LV volume using the SD algorithm was increased by thickening the wall of the phantom. In the clinical study, the wall thickness and LV volume of OSEM and SD algorithms showed a difference between HCM and normal groups. The wall thickness using OSEM and SD algorithms were 19.4 ± 2.0 and 16.7 ± 1.5 mm in patients with normal, and 27.9 ± 4.9 and 21.8 ± 2.6 mm in patients with HCM.

Conclusion: The SD algorithm in cases of HCM may not be able to correctly assess wall thickness and LV volume. Our study suggests that the OSEM is more suitable in cases of HCM than the SD algorithm.

Keywords: LV volume; Myocardial perfusion imaging; ordered-subsets expectation maximization; spatial resolution; wall thickness.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Algorithms*
  • Cadmium
  • Cardiomyopathy, Hypertrophic / diagnostic imaging*
  • Cohort Studies
  • Female
  • Heart Ventricles / diagnostic imaging
  • Humans
  • Image Processing, Computer-Assisted*
  • Male
  • Middle Aged
  • Myocardial Perfusion Imaging
  • Phantoms, Imaging
  • Tellurium
  • Tomography, Emission-Computed, Single-Photon*
  • Zinc


  • CdZnTe
  • Cadmium
  • Zinc
  • Tellurium