Corneal keloid presenting forty years after penetrating injury: Case report and literature review

Surv Ophthalmol. Sep-Oct 2019;64(5):700-706. doi: 10.1016/j.survophthal.2019.02.010. Epub 2019 Mar 6.


A 64-year-old Caucasian man had been diagnosed with presumed ocular surface squamous neoplasia in the left eye and started on topical interferon alpha 2b drops. When we saw him, he provided a history of penetrating corneal injury more than forty years before. Slit lamp examination revealed a large, elevated, opaque lesion involving the left cornea. High-definition anterior segment optical coherence tomography revealed a hyperreflective lesion involving the anterior stroma with a relatively normal overlying epithelium. Based on the clinical history, slit lamp, and anterior segment optical coherence tomography findings, a giant corneal keloid was suspected, and the interferon drops were discontinued. He subsequently underwent a penetrating keratoplasty, and histopathologic analysis was consistent with corneal keloid. Corneal keloids may be seen decades after the initial trauma, and anterior segment optical coherence tomography can be a useful tool in differentiating these tumor-like lesions from other neoplasia.

Keywords: anterior segment ocular coherence tomography; cornea; histopathology; immunohistochemical staining; keloid; ocular surface squamous neoplasia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Cornea / pathology*
  • Cornea / surgery
  • Corneal Diseases / diagnosis
  • Corneal Diseases / etiology*
  • Corneal Diseases / surgery
  • Eye Injuries, Penetrating / complications*
  • Humans
  • Keloid / diagnosis
  • Keloid / etiology*
  • Keloid / surgery
  • Keratoplasty, Penetrating / methods
  • Male
  • Middle Aged
  • Slit Lamp Microscopy
  • Tomography, Optical Coherence