Skin allograft rejection by L3/T4+ and Lyt-2+ T cell subsets

Transplantation. 1986 May;41(5):634-9. doi: 10.1097/00007890-198605000-00016.

Abstract

The L3/T4+ and Lyt-2+ T-cell subsets can be depleted from mice, using selected monoclonal antibodies in vivo, at different times during rejection of, or priming to, allogeneic skin grafts. Although L3/T4+ cells are sufficient to reject skin grafts in naive Lyt-2-depleted mice, we show that Lyt-2+ cells can become involved, after an initial delay, in intact mice. Furthermore, these Lyt-2+ cells are primed to dominate the accelerated rejection of a normal secondary response. Mice depleted of L3/T4+ cells cannot be primed in this way, suggesting that priming of Lyt-2+ cells is dependent on help from L3/T4+ cells. However, in mice depleted of Lyt-2+ cells, priming for rapid rejection can be achieved, presumably via the L3/T4+ population. This suggests that the rejection of skin allografts in a given situation reflects different contributions of multiple effector mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Ly / immunology*
  • Antigens, Surface / analysis*
  • Graft Rejection
  • Mice
  • Mice, Inbred Strains
  • Minor Histocompatibility Loci
  • Rats
  • Skin Transplantation*
  • T-Lymphocytes / classification
  • T-Lymphocytes / immunology*
  • Thymectomy

Substances

  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Ly
  • Antigens, Surface