Growth of Pulmonary Arteriovenous Malformations in Pediatric Patients with Hereditary Hemorrhagic Telangiectasia

Anina Ratjen; Jacky Au; Susan Carpenter; Philip John; Felix Ratjen

doi:10.1016/j.jpeds.2018.12.069

Growth of Pulmonary Arteriovenous Malformations in Pediatric Patients with Hereditary Hemorrhagic Telangiectasia

J Pediatr. 2019 May:208:279-281. doi: 10.1016/j.jpeds.2018.12.069. Epub 2019 Mar 8.

Authors

Anina Ratjen¹, Jacky Au², Susan Carpenter¹, Philip John³, Felix Ratjen⁴

Affiliations

¹ Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
² Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
³ Interventional Radiology, Hospital for Sick Children, Toronto, Ontario, Canada.
⁴ Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada; Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. Electronic address: Felix.ratjen@sickkids.ca.

PMID: 30853205
DOI: 10.1016/j.jpeds.2018.12.069

Abstract

The evolution of pulmonary arteriovenous malformations (PAVMs) over time in children with hereditary hemorrhagic telangiectasia (HHT) is not well-defined. Herein we demonstrate that, although new PAVMs did not evolve in children with HHT, existing PAVMs exhibit quantitative growth over time highlighting the need for ongoing follow-up throughout childhood.

Keywords: arteriovenous malformations; children; hereditary hemorrhagic telangiectasia.

MeSH terms

Adolescent
Arteriovenous Fistula / complications*
Arteriovenous Fistula / diagnostic imaging
Arteriovenous Fistula / genetics
Arteriovenous Malformations / complications*
Arteriovenous Malformations / diagnostic imaging
Arteriovenous Malformations / genetics
Child
Child, Preschool
Female
Humans
Lung / diagnostic imaging
Male
Mutation
Pulmonary Artery / abnormalities*
Pulmonary Artery / diagnostic imaging
Pulmonary Veins / abnormalities*
Pulmonary Veins / diagnostic imaging
Regression Analysis
Retrospective Studies
Telangiectasia, Hereditary Hemorrhagic / complications*
Telangiectasia, Hereditary Hemorrhagic / diagnostic imaging
Telangiectasia, Hereditary Hemorrhagic / genetics

Supplementary concepts

Pulmonary Arteriovenous Fistulas