Successful management of epithelial ingrowth after sequential intracameral 5-fluorouracil and Descemet-stripping automated endothelial keratoplasty

J Cataract Refract Surg. 2019 May;45(5):690-693. doi: 10.1016/j.jcrs.2018.12.030. Epub 2019 Mar 8.


To describe the successful treatment of epithelial ingrowth using combined surgical excision with intracameral adjuvant 5-fluorouracil (5-FU) followed by Descemet-stripping automated endothelial keratoplasty (DSAEK). A 71-year-old man presented with epithelial ingrowth after clear corneal phacoemulsification. He underwent surgical excision of the membrane together with pars plana vitrectomy, air fluid exchange, and intracameral 5-FU. This treatment resulted in corneal decompensation for which DSAEK was performed 6 months later. Despite interface haze, the postoperative corrected distance visual acuity returned to 20/40 three months after DSAEK. There was no clinical evidence of recurrence of the epithelial ingrowth 9 months after the surgical removal. Intracameral 5-FU can be used in conjunction with surgical excision and subsequent DSAEK to successfully treat epithelial ingrowth.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anterior Chamber / pathology*
  • Antimetabolites / therapeutic use*
  • Combined Modality Therapy
  • Cornea / surgery
  • Corneal Diseases / drug therapy
  • Corneal Diseases / pathology
  • Corneal Diseases / surgery
  • Corneal Diseases / therapy*
  • Descemet Stripping Endothelial Keratoplasty*
  • Epithelium, Corneal / pathology*
  • Fluorouracil / therapeutic use*
  • Humans
  • Male
  • Phacoemulsification
  • Slit Lamp Microscopy


  • Antimetabolites
  • Fluorouracil