Manganese: Its Role in Disease and Health

Met Ions Life Sci. 2019 Jan 14;19:/books/9783110527872/9783110527872-016/9783110527872-016.xml. doi: 10.1515/9783110527872-016.


Manganese is an essential dietary element that functions primarily as a coenzyme in several biological processes. These processes include, but are not limited to, macronutrient metabolism, bone formation, free radical defense systems, and in the brain, ammonia clearance and neurotransmitter synthesis. It is a critical component in dozens of proteins and enzymes, and is found in all tissues. Concentrated levels of Mn are found in tissues rich in mitochondria and melanin, with both, liver, and pancreas having the highest concentrations under normal conditions. However, overexposure to environmental Mn via industrial occupation or contaminated drinking water can lead to toxic brain Mn accumulation that has been associated with neurological impairment. The objective of this chapter is to address the biological importance of Mn (essentiality), routes of exposure, factors dictating Mn status, a brief discussion of Mn neurotoxicity, and proposed methods for neurotoxicity remediation.

Publication types

  • Review

MeSH terms

  • Brain Chemistry*
  • Humans
  • Manganese / physiology*
  • Manganese / toxicity*


  • Manganese