Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: An approach for their use in neural regeneration therapies

PLoS One. 2019 Mar 11;14(3):e0213032. doi: 10.1371/journal.pone.0213032. eCollection 2019.


Mesenchymal stem cells (MSCs) can trans/differentiate to neural precursors and/or mature neurons and promote neuroprotection and neurogenesis. The above could greatly benefit neurodegenerative disorders as well as in the treatment of post-traumatic and hereditary diseases of the central nervous system (CNS). In order to attain an ideal source of adult MSCs for the treatment of CNS diseases, adipose tissue, bone marrow, skin and umbilical cord derived MSCs were isolated and studied to explore differences with regard to neural differentiation capacity. In this study, we demonstrated that MSCs from several tissues can differentiate into neuron-like cells and differentially express progenitors and mature neural markers. Adipose tissue MSCs exhibited significantly higher expression of neural markers and had a faster proliferation rate. Our results suggest that adipose tissue MSCs are the best candidates for the use in neurological diseases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / cytology
  • Adult
  • Bone Marrow Cells / physiology
  • Cell Proliferation
  • Cell- and Tissue-Based Therapy / methods
  • Cells, Cultured
  • Central Nervous System Diseases / therapy
  • Chile
  • Female
  • Humans
  • Male
  • Mesenchymal Stem Cells / physiology*
  • Nerve Regeneration*
  • Neurogenesis*
  • Primary Cell Culture
  • Regenerative Medicine / methods
  • Skin / cytology
  • Umbilical Cord / cytology
  • Young Adult

Grants and funding

This study was supported by RM-13IEAT-20943 from innova Corfo,, CJ, and PI2013-DA001 from Academic Direction of Clinica Las Condes,