Molecular characterization and pathogenicity determination of hypervirulent Klebsiella pneumoniae clinical isolates serotype K2 in Mexico

Diagn Microbiol Infect Dis. 2019 Jul;94(3):316-319. doi: 10.1016/j.diagmicrobio.2019.01.013. Epub 2019 Jan 31.

Abstract

Hypervirulent Klebsiella pneumoniae have been rarely described in Latin America. This work describes the characterization of hypervirulent K. pneumoniae isolates capsular serotype K2 belonging to sequence types 86 and 380. The assays showed the hypervirulent K. pneumoniae highly virulent, which is determined by the plasmid borne virulence genes. At this time, the hypervirulent K. pneumoniae clinical isolates in Mexico are extensively susceptible to antibiotics.

Keywords: Hypervirulent; K2 serotype; Klebsiella pneumoniae.

Publication types

  • Letter

MeSH terms

  • Animals
  • Cell Adhesion
  • Disease Models, Animal
  • Female
  • Genotype*
  • Humans
  • Klebsiella Infections / microbiology*
  • Klebsiella Infections / pathology*
  • Klebsiella pneumoniae / classification*
  • Klebsiella pneumoniae / isolation & purification
  • Klebsiella pneumoniae / pathogenicity*
  • Lethal Dose 50
  • Male
  • Mexico
  • Mice, Inbred BALB C
  • Microbial Sensitivity Tests
  • Models, Biological
  • Plasmids / analysis
  • Serogroup*
  • Virulence Factors / genetics

Substances

  • Virulence Factors