Current concepts in vitamin D and orthopaedic surgery

Orthop Traumatol Surg Res. 2019 Apr;105(2):375-382. doi: 10.1016/j.otsr.2018.12.006. Epub 2019 Mar 8.


Introduction: Vitamin D plays an important role in the musculoskeletal system of the human body. Here, we review the most current literature on vitamin D as it relates to orthopaedic surgery and the musculoskeletal system, focusing largely on non-fracture applications.

Materials and methods: A literature review was performed on the basic science of vitamin D metabolism, epidemiology of vitamin D levels, role of vitamin D within the musculoskeletal system, and the correlation of vitamin D with injuries and orthopaedic surgical outcomes.

Results: The existing literature suggests vitamin D plays multiple roles in the musculoskeletal system. Recent research has shed light on the importance of vitamin D in the setting of soft tissue healing and recovery in addition to affecting postoperative outcomes after common orthopaedic procedures.

Conclusions: Given the widespread prevalence of vitamin D deficiency, orthopaedic surgeons should be aware of the current evidence regarding clinical implications in patients with musculoskeletal complaints.

Keywords: ACL reconstruction; Arthroplasty; Athletes; Muscle function; Osteoarthritis; Rotator cuff injury; Vitamin D.

Publication types

  • Review

MeSH terms

  • Global Health
  • Humans
  • Incidence
  • Orthopedic Procedures / methods*
  • Postoperative Complications / epidemiology
  • Postoperative Complications / prevention & control*
  • Prevalence
  • Risk Factors
  • Vitamin D / pharmacokinetics*
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / metabolism
  • Vitamins / pharmacokinetics


  • Vitamins
  • Vitamin D