Onward and [K +]Upward: a New Potassium Importer under the Spell of Cyclic di-AMP

J Bacteriol. 2019 Apr 24;201(10):e00150-19. doi: 10.1128/JB.00150-19. Print 2019 May 15.

Abstract

Cyclic di-AMP (c-di-AMP) is a second messenger which plays a major role in osmotic homeostasis in bacteria. In work by Quintana et al. (I. M. Quintana, J. Gibhardt, A. Turdiev, E. Hammer, et al., J Bacteriol 201:e00028-19, 2019, https://doi.org/10.1128/jb.00028-19), two Kup homologs from Lactococcus lactis were identified as high-affinity K+ importers whose activities are inhibited by direct binding of c-di-AMP. The results broaden the scope of K+ level regulation by c-di-AMP, with Kup homologs found in a number of pathogenic, commensal, and industrial bacteria.

Keywords: Lactococcus; cyclic di-AMP; osmotic stress; potassium uptake; second messenger.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenosine Monophosphate
  • Bacterial Proteins
  • Cyclic AMP
  • Cyclic AMP Receptor Protein
  • Dinucleoside Phosphates
  • Lactococcus lactis*
  • Potassium

Substances

  • Bacterial Proteins
  • Cyclic AMP Receptor Protein
  • Dinucleoside Phosphates
  • Adenosine Monophosphate
  • Cyclic AMP
  • Potassium