Severity of Substance Use Disorder: Utility as an Outcome in Clinical Settings

Alcohol Clin Exp Res. 2019 May;43(5):869-876. doi: 10.1111/acer.14020. Epub 2019 Mar 29.

Abstract

Background: Some authors have pointed out the usefulness of the levels of substance use disorder (SUD) as a treatment outcome. However, in order to use this variable as an outcome measure, its impact needs to be addressed within a clinical context. The aim of this study was to analyze the sensitivity of SUD levels as a measure for detecting reliable changes and to make a comparison between the changes in SUD levels detected when using the number of criteria fulfilled and when using the reliable change index (RCI).

Methods: The sample consisted of 206 (106 in follow-up) patients diagnosed with abuse/dependence on alcohol and cocaine, according to DSM-IV criteria. The Substance Dependence Severity Scale for DSM-5 was used to determine current alcohol use disorder (AUD) and cocaine use disorder (CUD). Number of DSM-5 criteria fulfilled and RCI were used to determine the change in SUD levels.

Results: No association was found between adherence to/abandonment of treatment and AUD severity levels (χ2 = 7.029, p = 0.071) or CUD severity levels (χ2 = 2.044, p = 0.413). Statistical significant differences for levels of AUD (z = -3.870, p = 0.000) and CUD (z = -5.382, p = 0.000) were found between baseline assessment and follow-up. According to the number of DSM-5 criteria and RCI, the Kappa coefficient for the change in patient status (improved, worsened, or no change) was k = 0.61 for alcohol patients and k = 0.64 for cocaine patients. The "mild" category showed the greatest inconsistency between both procedures.

Conclusions: Levels of SUD are sensitive to the impact of treatment as measured by the difference between the baseline assessment and 3-month follow-up. However, conclusions differ according to whether the DSM-5 criteria or the RCI is applied.

Keywords: Alcohol Use Disorders; Cocaine Use Disorders; Levels of SUD; Outcome; Reliable Change Index.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Data Interpretation, Statistical*
  • Diagnostic and Statistical Manual of Mental Disorders*
  • Female
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male
  • Patient Acceptance of Health Care*
  • Severity of Illness Index*
  • Substance-Related Disorders / diagnosis*
  • Substance-Related Disorders / epidemiology*
  • Substance-Related Disorders / therapy
  • Treatment Outcome