Embryonic Immune Cells Remodel the Heart

Stephanie Grainger; David Traver

doi:10.1016/j.devcel.2019.02.017

Embryonic Immune Cells Remodel the Heart

Dev Cell. 2019 Mar 11;48(5):595-596. doi: 10.1016/j.devcel.2019.02.017.

Authors

Stephanie Grainger¹, David Traver²

Affiliations

¹ Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: sgrainger@ucsd.edu.
² Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: dtraver@ucsd.edu.

PMID: 30861372
DOI: 10.1016/j.devcel.2019.02.017

Abstract

How the products of transient hematopoiesis in the yolk sac, dorsal aorta, and developing heart tube function at their sites of production is poorly understood. In this issue of Developmental Cell, Shigeta et al. (2019) elegantly demonstrate that macrophages derived from the heart tube contribute to local tissue remodeling during valve development.

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MeSH terms

Embryo, Mammalian
Heart*
Hematopoiesis
Macrophages
Yolk Sac*