Embryonic Immune Cells Remodel the Heart

Dev Cell. 2019 Mar 11;48(5):595-596. doi: 10.1016/j.devcel.2019.02.017.


How the products of transient hematopoiesis in the yolk sac, dorsal aorta, and developing heart tube function at their sites of production is poorly understood. In this issue of Developmental Cell, Shigeta et al. (2019) elegantly demonstrate that macrophages derived from the heart tube contribute to local tissue remodeling during valve development.

Publication types

  • Comment

MeSH terms

  • Embryo, Mammalian
  • Heart*
  • Hematopoiesis
  • Macrophages
  • Yolk Sac*