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. 2019 Mar;24(10):1900147.
doi: 10.2807/1560-7917.ES.2019.24.10.1900147.

Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018

David W Eyre  1   2 , Katy Town  3 , Teresa Street  2 , Leanne Barker  2 , Nicholas Sanderson  2 , Michelle J Cole  3 , Hamish Mohammed  3 , Rachel Pitt  3 , Maya Gobin  3 , Charles Irish  3 , Daniel Gardiner  3 , James Sedgwick  3 , Charles Beck  3 , John Saunders  3 , Deborah Turbitt  3 , Clare Cook  3 , Nick Phin  3 , Bavithra Nathan  3   4 , Paddy Horner  3   5   4 , Helen Fifer  3   4
Affiliations

Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018

David W Eyre et al. Euro Surveill. 2019 Mar.

Abstract

We describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome sequences. Urgent action is essential to contain this drug-resistant strain.

Keywords: antimicrobial resistance; antimicrobial treatment; gonorrhoeae; treatment failure; whole-genome sequencing.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Ceftriaxone-resistant Neisseria gonorrhoeae isolates (n=15), including from Case 1 and Case 2, United Kingdom, 2018
Figure 2
Figure 2
Time-dated Bayesian phylogeny of Neisseria gonorrhoeae FC428 clone cases and epidemiological details, 2015–2019 (n = 10)
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