Host Lipids in Positive-Strand RNA Virus Genome Replication

Front Microbiol. 2019 Feb 26;10:286. doi: 10.3389/fmicb.2019.00286. eCollection 2019.


Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.

Keywords: lipid metabolism; membrane association; phospholipids; positive-strand RNA virus; viral RNA replication.

Publication types

  • Review