The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial

Phytother Res. 2019 May;33(5):1374-1383. doi: 10.1002/ptr.6328. Epub 2019 Mar 12.


Diabetes mellitus is one of the most common and important metabolic diseases in human. Curcumin, which is a natural polyphenol found in turmeric, can be used in treatment of diabetes complications for its antidiabetic, anti-inflammatory, and antioxidant properties. In this double-blind randomized clinical trial, 44 patients with Type 2 diabetes randomly assigned to curcumin or placebo group. Patients consumed either 1,500-mg curcumin or placebo daily for 10 weeks. Anthropometric measurements were measured at baseline and at the end of the study. Serum concentrations of triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and adiponectin were determined after 12-hr fasting at the beginning and end of study. The mean serum level of TG decreased in curcumin group compared with baseline (109 ± 36 vs. 124 ± 36; p < 0.05). At the end of study, the mean concentration of high-sensitivity C-reactive protein decreased in the curcumin group compared to the control (2.9 ± 2.9 vs. 3.4 ± 4.2; p < 0.05). The mean serum concentration of adiponectin increased (64 ± 3 vs. 63 ± 4; p < 0.05) in the treatment group compared with the placebo at the end of the study. The results of the current study indicate that curcumin consumption may reduce diabetes complications through decreasing TG level as well as indicators of inflammation.

Keywords: adiponectin; curcumin; diabetes type 2; inflammation; lipid profile.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiponectin / blood*
  • Adult
  • Aged
  • Antioxidants / therapeutic use
  • C-Reactive Protein / metabolism*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Curcuma / chemistry
  • Curcumin / pharmacology*
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dietary Supplements
  • Double-Blind Method
  • Fasting
  • Female
  • Humans
  • Inflammation / drug therapy
  • Lipids / blood
  • Male
  • Middle Aged
  • Triglycerides / blood


  • ADIPOQ protein, human
  • Adiponectin
  • Antioxidants
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipids
  • Triglycerides
  • C-Reactive Protein
  • Curcumin