Beyond the sleep-amyloid interactions in Alzheimer's disease pathogenesis

J Neurophysiol. 2019 Jul 1;122(1):1-4. doi: 10.1152/jn.00118.2019. Epub 2019 Mar 13.


Cognitive impairment in older adults is associated with sleep and circadian rhythm disturbances. Numerous studies have linked disrupted sleep and circadian rhythms with amyloid-β (Aβ), a key pathological hallmark in Alzheimer's disease (AD). While previous evidence suggests that Aβ initiates AD pathogenesis, tau, another major hallmark of AD, seems to drive neurodegeneration. Recent studies imply that sleep-wake cycles affect brain tau more significantly than Aβ levels, leading to accelerated AD progression and cognitive decline. The study of sleep disturbances in AD is shedding light on our understanding of the mechanism underlying sleep disturbances in AD and dementia.

Keywords: Alzheimer’s disease; amyloid-β; sleep; tau.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / complications
  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Circadian Rhythm
  • Humans
  • Sleep Wake Disorders / etiology
  • Sleep Wake Disorders / metabolism*
  • tau Proteins / metabolism


  • Amyloid beta-Peptides
  • tau Proteins