Gender and time delays in diagnosis of pulmonary tuberculosis: a cross-sectional study from China

Epidemiol Infect. 2019 Jan:147:e94. doi: 10.1017/S0950268819000049.

Abstract

Gender inequality has severe consequences on public health in terms of delay in diagnosis of pulmonary tuberculosis (PTB). In order to explore gender-related differences in diagnosis delay, a cross-sectional study of 10 686 patients diagnosed with PTB in Yulin from 1 January 2009 to 31 December 2014 was conducted. Diagnosis delay was categorised into 'short delay' and 'long delay' by four commonly used cut-off points of 14, 30, 60 and 90 days. Logistic regression analysis was used to analyse gender differences in diagnostic delay. Stratified analyses by smear results, age, urban/rural were performed to examine whether the effect persisted across the strata. The median delay was 31 days (interquartile range 13-65). Diagnostic delay in females at cut-off points of 14, 30, 60 and 90 days had odds ratios (OR) of 0.99 (95% CI 0.91-1.09), 1.09 (95% CI 1.01-1.18), 1.15 (95% CI 1.05-1.26) and 1.18 (95% CI 1.06-1.31), respectively, compared with males. Stratified analysis showed that females were associated with increased risk of longer delay among those aged 30-60 years, smear positive and living in the rural areas (P < 0.05). The female-to-male OR increased along with increased delay time. Further inquiry into the underlying reasons for gender differences should be urgently addressed to improve the current situation.

Keywords: Community epidemics; infectious disease epidemiology; meningitis – tuberculous; public health.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • China
  • Cross-Sectional Studies
  • Delayed Diagnosis / statistics & numerical data*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Rural Population / statistics & numerical data
  • Sex Factors
  • Time Factors
  • Tuberculosis, Pulmonary / diagnosis*
  • Urban Population / statistics & numerical data
  • Young Adult