Double-headed nanosystems for oral drug delivery

Chem Commun (Camb). 2019 Apr 18;55(33):4761-4764. doi: 10.1039/c8cc10021g.


We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces. The in vivo results suggest that the bioavailability of encapsulated curcumin is proportional to the ligand density rendered by double-headed nanosystems.

MeSH terms

  • Administration, Oral
  • Biological Availability
  • Curcumin / administration & dosage
  • Curcumin / pharmacokinetics
  • Drug Delivery Systems*
  • Nanoparticles*
  • Spectrum Analysis / methods


  • Curcumin