Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection With Bacteriophages and Antibiotics Combination

Clin Infect Dis. 2019 Nov 13;69(11):2015-2018. doi: 10.1093/cid/ciz222.


A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.

Keywords: antibiotic resistance; bacteriophage; orthopedic infections; phage; phage therapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / therapy
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / pathogenicity
  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteriophages / physiology*
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Humans
  • Klebsiella pneumoniae / pathogenicity
  • Male
  • Wound Infection / drug therapy*
  • Wound Infection / therapy*


  • Anti-Bacterial Agents