Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants

PLoS One. 2019 Mar 14;14(3):e0213537. doi: 10.1371/journal.pone.0213537. eCollection 2019.


Aim: We hypothesized that compromised cardiac output in asphyxiated infants may influence on the rate of disappearance of lactate due to insufficient perfusion.

Methods: The study was a prospective, observational study, where infants with perinatal asphyxia who met the criteria for therapeutic hypothermia were included. Cardiac output, stroke volume and heart rate were measured by electrical velocimetry in 15 newborn infants with perinatal asphyxia during the first six hours of active therapeutic hypothermia. Results from routine blood samples were collected retrospectively. Cardiac parameters were also measured in 10 healthy, term infants after caesarian section. Cardiac parameters were compared between the asphyxiated group and the control group prior to and during hypothermia. Rate of disappearance of lactate was correlated to cardiac output in the asphyxiated infants.

Results: Cardiac output was stable in the healthy infants from 0.5 to 6 hours postnatally. The infants with perinatal asphyxia had lower cardiac output prior to and during therapeutic hypothermia compared to the control group. Rate of disappearance of lactate was not related to cardiac output.

Conclusion: An association between disappearance of lactate acidosis and low cardiac output was not confirmed. A low rate of disappearance of lactate may rather be an indicator of organ injury due to asphyxia.

Publication types

  • Clinical Trial
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acidosis, Lactic / blood
  • Acidosis, Lactic / physiopathology
  • Acidosis, Lactic / therapy
  • Asphyxia Neonatorum / blood
  • Asphyxia Neonatorum / physiopathology
  • Asphyxia Neonatorum / therapy*
  • Cardiac Output
  • Female
  • Humans
  • Hypothermia, Induced*
  • Infant, Newborn
  • Lactic Acid / blood
  • Male
  • Prospective Studies


  • Lactic Acid

Associated data

  • figshare/10.6084/m9.figshare.7796621.v1

Grant support

The study was financially supported by University of Copenhagen (VRE) and The Augustinus Foundation, Denmark (GHH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.