Recent trends in invasive group A Streptococcus disease in Victoria

Jane Oliver; Mathilda Wilmot; Janet Strachan; Siobhan St George; Courtney R Lane; Susan A Ballard; Michelle Sait; Katherine Gibney; Benjamin P Howden; Deborah A Williamson

doi:10.33321/cdi.2019.43.8

Recent trends in invasive group A Streptococcus disease in Victoria

Commun Dis Intell (2018). 2019 Mar 15:43. doi: 10.33321/cdi.2019.43.8.

Affiliations

¹ Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria, Australia, 3000 - Murdoch Children’s Research Institute, Royal Children’s Hospital, 50 Flemington Rd, Parkville, Victoria, Australia, 3052
² Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria, Australia, 3000

PMID: 30879286
DOI: 10.33321/cdi.2019.43.8

Abstract

Background: Invasive Group A Streptococcus (iGAS) disease can cause permanent disability and death. The incidence of iGAS has increased in many developed countries since the 1980s. iGAS disease is not nationally notifiable in Australia or at the state level in Victoria. The Victorian Hospital Pathogen Surveillance Scheme (VHPSS) is a voluntary laboratory-based surveillance system established in 1988. We assessed the trends and molecular epidemiology of iGAS disease in Victoria from 2007-2017.

Methods: A case of iGAS was defined as an individual for whom Group A Streptococcus (GAS) was isolated from a normally sterile body site. Data on all iGAS cases, as reported to the VHPSS, between 1 January 2007 and 31 December 2017 were examined.

Results: A total of 1,311 iGAS cases had associated isolates, and M Protein Gene (emm) typing was performed for 91.6%. The mean annual incidence was 2.1 (95% CI: 1.8-2.5) per 100,000 population per year, increasing 2.7-fold over the study period. In total, 140 different iGAS emm-types were observed, with the ten most prevalent types comprising 63.1% of the sample.

Conclusions: Despite limitations in this surveillance data, we observed increasing rates of iGAS disease in Victoria. iGAS incidence exceeded the mean annual incidence for invasive meningococcal disease, calculated using Victorian data from the National Notifiable Diseases Surveillance System (2.1 vs. 0.6 cases per 100,000 population per year, respectively). Mandatory case notification could enhance disease control and prevention. Further, the diversity in emm-types emphasises the importance of effective secondary chemoprophylaxis in prevention, alongside GAS vaccine development.

Keywords: Invasive disease; group A Streptococcus; invasive group A Streptococcus disease; Victoria public health; disease control; surveillance; disease prevention; infectious diseases; epidemiology.