Therapeutic Potential of Helminths and Helminth-Derived Antigens for Resolution of Inflammation in Inflammatory Bowel Disease

Amir Abdoli

doi:10.1016/j.arcmed.2019.03.001

Therapeutic Potential of Helminths and Helminth-Derived Antigens for Resolution of Inflammation in Inflammatory Bowel Disease

Arch Med Res. 2019 Jan;50(1):58-59. doi: 10.1016/j.arcmed.2019.03.001. Epub 2019 Mar 14.

Author

Amir Abdoli¹

Affiliation

¹ Department of Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran; Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran; Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran. Electronic address: a.abdoli25@gmail.com.

PMID: 30879759
DOI: 10.1016/j.arcmed.2019.03.001

Abstract

Inflammation plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD), and treatment of IBD mainly targets on inhibition of pro-inflammatory mediators. Helminth-based therapy is a novel strategy for resolution of inflammation in IBD, because helminths have great immunomodulatory properties. Helminth-based therapy may be efficacious as a vaccine for patients with IBD. This article is a highlight on the therapeutic potential of helminths in IBD.

Keywords: Crohn's disease (CD); Helminths; Immunoregulation; Inflammatory bowel disease (IBD); Ulcerative colitis (UC).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Helminth / therapeutic use*
Colitis, Ulcerative / therapy*
Crohn Disease / therapy*
Helminths / immunology*
Humans
Inflammation / therapy
Male

Substances

Antigens, Helminth