Therapeutic Potential of Helminths and Helminth-Derived Antigens for Resolution of Inflammation in Inflammatory Bowel Disease

Arch Med Res. 2019 Jan;50(1):58-59. doi: 10.1016/j.arcmed.2019.03.001. Epub 2019 Mar 14.

Abstract

Inflammation plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD), and treatment of IBD mainly targets on inhibition of pro-inflammatory mediators. Helminth-based therapy is a novel strategy for resolution of inflammation in IBD, because helminths have great immunomodulatory properties. Helminth-based therapy may be efficacious as a vaccine for patients with IBD. This article is a highlight on the therapeutic potential of helminths in IBD.

Keywords: Crohn's disease (CD); Helminths; Immunoregulation; Inflammatory bowel disease (IBD); Ulcerative colitis (UC).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Helminth / therapeutic use*
  • Colitis, Ulcerative / therapy*
  • Crohn Disease / therapy*
  • Helminths / immunology*
  • Humans
  • Inflammation / therapy
  • Male

Substances

  • Antigens, Helminth