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, 2019, 7568410
eCollection

B and NK Cells Closely Correlate With the Condition of Patients With Acute Pancreatitis

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B and NK Cells Closely Correlate With the Condition of Patients With Acute Pancreatitis

Xin Wei et al. Gastroenterol Res Pract.

Abstract

Purpose: Pancreatitis can lead to systemic inflammatory response, but the relationship between lymphocyte changes and patients with pancreatitis remains unclear. In this study, we evaluated the feedback function of changes in peripheral lymphocyte subsets on the condition of patients with pancreatitis.

Materials and methods: 131 acute pancreatitis (AP) patients and 11 chronic pancreatitis (CP) patients constituted the patients' group; 20 healthy individuals were enrolled as healthy controls (HC). Serum concentration of C-reactive protein (CRP), amylase, and lipase and the frequency and absolute number of many types of peripheral lymphocytes (including T, B, NK, CD16+/CD56+ T, CD4+ T, CD8+ T, CD4+CD8+ T, and CD4-CD8- T cells) were detected on admission and the seventh day of standard treatment. Besides, the length of hospital stay was recorded.

Results: The absolute number of all lymphocytes we studied decreased in patients with CP and in patients with almost all types of AP. The frequency change of lymphocytes varies among the different types of AP. During disease onset, B cell frequency correlated positively with CRP concentration and NK cell frequency correlated positively with amylase and lipase concentration. B cell frequency and CD4+ T cell absolute number were recovering towards normal after short-term treatment. The frequency of B cells and NK cells correlated positively with the length of hospital stay.

Conclusions: B cells and NK cells closely correlate with patients' condition and may help to diagnose AP more accurately and reflect treatment effect of AP in time, affecting the recovery speed of patients with M-AP, which may help physicians to better understand the pathophysiology of pancreatitis.

Figures

Figure 1
Figure 1
The frequency of peripheral lymphocyte subsets in patients with AP or CP. Pooled data indicating the peripheral lymphocyte subsets (B, NK, T, CD4+ T, CD8+ T, CD4/CD8, DN T, DP T, and NKT) as a proportion of total lymphocytes. ∗∗∗P < 0.001, ∗∗P < 0.01, and P < 0.05.
Figure 2
Figure 2
The frequency of peripheral lymphocyte subsets in patients with M-AP or S-AP. Pooled data indicating the peripheral lymphocyte subsets (B, NK, T, CD4+ T, CD8+ T, CD4/CD8, DN T, DP T, and NKT) as a proportion of total lymphocytes.
Figure 3
Figure 3
The frequency of peripheral lymphocyte subsets in patients with AP caused by different etiologies. Pooled data indicating the peripheral lymphocyte subsets (B, NK, T, CD4+ T, CD8+ T, CD4/CD8, DN T, DP T, and NKT) as a proportion of total lymphocytes.
Figure 4
Figure 4
Correlations between B cell frequency and pancreatitis-related diagnostic indicator (CRP) in patients with AP. These data indicate that B cell-frequency and serum CRP concentration have a good positive correlation.
Figure 5
Figure 5
Correlations between NK cell frequency and pancreatitis-related diagnostic indicators (amylase and lipase) in patients with AP. These data indicate that NK cell-frequency and serum amylase and lipase activity concentration have a good positive correlation in patients with M-AP.
Figure 6
Figure 6
The changes of peripheral lymphocyte subsets (B cells and CD4+ T cells) before and after treatment in patients with AP. The arrow next to BT represents the trend of lymphocyte changes when comparing BT with HC. The arrow next to AT represents the trend of lymphocyte changes when comparing AT with BT.
Figure 7
Figure 7
Correlations between the frequency of peripheral lymphocyte subsets (B and NK cells) at admission and hospitalization time in patients with AP. These data suggest that the frequency of B cells and NK cells is positively correlated with hospitalization time in patients with M-AP.

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