Salivary 1,5-Anhydroglucitol and Vitamin Levels in Relation to Caries Risk in Children

Biomed Res Int. 2019 Feb 7;2019:4503450. doi: 10.1155/2019/4503450. eCollection 2019.


The objective of this study was to evaluate the association between salivary 1,5-anhydroglucitol (AG), vitamins A (VA), C (VC), and E (VE), and caries risk in children. 100 healthy children aged between 6 and 13 years were divided into two equal groups of caries-free (DMFS/dmfs=0) and caries active (DMFS/dmfs>3). Unstimulated midmorning saliva was collected from all the children and the levels of salivary AG and vitamins A, C, and E were measured. Caries risk assessment was done using American Academy of Pediatric Dentistry Caries Assessment Tool. Analysis of salivary AG and vitamins was performed using a commercially available ELISA kit. Low levels of AG were present in caries active and high caries risk groups compared to caries-free and low/medium caries risk groups. This difference is statistically significant (p < 0.05). A strong negative correlation between AG and caries activity was observed in the caries active group. VA was not related to caries activity, while VC and VE displayed a statistically significant correlation (p < 0.05). Similarly, a strong negative correlation was observed between the levels of AG and high caries risk group. Salivary AG, VC, and VE together are related to caries risk in caries active children. These salivary parameters can act as indicator of caries status in children.

MeSH terms

  • Adolescent
  • Ascorbic Acid / isolation & purification
  • Ascorbic Acid / metabolism*
  • Child
  • Dental Caries / epidemiology
  • Dental Caries / metabolism*
  • Dental Caries / pathology
  • Deoxyglucose / isolation & purification
  • Deoxyglucose / metabolism
  • Female
  • Humans
  • Male
  • Risk Factors
  • Saliva / chemistry
  • Saliva / metabolism
  • Vitamin A / isolation & purification
  • Vitamin A / metabolism*
  • Vitamin E / isolation & purification
  • Vitamin E / metabolism*


  • Vitamin A
  • Vitamin E
  • 1,5-anhydroglucitol
  • Deoxyglucose
  • Ascorbic Acid