Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans

Emerg Infect Dis. 2019 Apr;25(4):823-825. doi: 10.3201/eid2504.171886.


We assessed Zika virus RNA and select cytokine levels in semen, blood, and plasma samples from an infected patient in South America. Viral RNA was detected in semen >2 months after viremia clearance; cytokine profiles differed in semen and plasma. After viremia, Zika virus appears to become compartmentalized in the male reproductive tract.

Publication types

  • Letter

MeSH terms

  • Biomarkers
  • Cytokines / blood
  • Cytokines / metabolism*
  • Host-Pathogen Interactions
  • Humans
  • Semen / metabolism*
  • Zika Virus Infection / blood
  • Zika Virus Infection / metabolism*
  • Zika Virus Infection / virology*
  • Zika Virus*


  • Biomarkers
  • Cytokines